Publications

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13 Publications visible to you, out of a total of 13

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Four enzymes of the gluconeogenic pathway in Sulfolobus solfataricus were purified and kinetically characterized. The enzymes were reconstituted in vitro to quantify the contribution of temperature instability of the pathway intermediates to carbon loss from the system. The reconstituted system, consisting of phosphoglycerate kinase, glyceraldehyde 3-phosphate dehydrogenase, triose phosphate isomerase and the fructose 1,6-bisphosphate aldolase/phosphatase, maintained a constant consumption rate of 3-phosphoglycerate and production of fructose 6-phosphate over a 1-h period. Cofactors ATP and NADPH were regenerated via pyruvate kinase and glucose dehydrogenase. A mathematical model was constructed on the basis of the kinetics of the purified enzymes and the measured half-life times of the pathway intermediates. The model quantitatively predicted the system fluxes and metabolite concentrations. Relative enzyme concentrations were chosen such that half the carbon in the system was lost due to degradation of the thermolabile intermediates dihydroxyacetone phosphate, glyceraldehyde 3-phosphate and 1,3-bisphosphoglycerate, indicating that intermediate instability at high temperature can significantly affect pathway efficiency.

Authors: T. Kouril, D. Esser, J. Kort, H. V. Westerhoff, B. Siebers, J. Snoep

Date Published: 8th May 2026

Publication Type: Journal Article

Abstract

Not specified

Authors: Benny Platte, Anett Platte, Rico Thomanek, Christian Roschke, Marc Ritter

Date Published: 16th Nov 2025

Publication Type: Book Chapter

Abstract

Not specified

Authors: Henry Völzke, Janka Schössow, Carsten Oliver Schmidt, Clemens Jürgens, Adrian Richter, André Werner, Nicole Werner, Dörte Radke, Alexander Teumer, Till Ittermann, Birgit Schauer, Vivien Henck, Nele Friedrich, Anke Hannemann, Theresa Winter, Matthias Nauck, Marcus Dörr, Martin Bahls, Stephan B Felix, Beate Stubbe, Ralf Ewert, Fabian Frost, Markus M Lerch, Hans J Grabe, Robin Bülow, Markus Otto, Norbert Hosten, Wolfgang Rathmann, Ulf Schminke, Rico Großjohann, Frank Tost, Georg Homuth, Uwe Völker, Stefan Weiss, Silva Holtfreter, Barbara M Bröker, Kathrin Zimmermann, Lars Kaderali, Marc Winnefeld, Boris Kristof, Klaus Berger, Stefanie Samietz, Christian Schwahn, Birte Holtfreter, Reiner Biffar, Stefan Kindler, Katharina Wittfeld, Wolfgang Hoffmann, Thomas Kocher

Date Published: 29th Mar 2022

Publication Type: Journal Article

Abstract

Not specified

Authors: Henry Völzke, Janka Schössow, Carsten Oliver Schmidt, Clemens Jürgens, Adrian Richter, André Werner, Nicole Werner, Dörte Radke, Alexander Teumer, Till Ittermann, Birgit Schauer, Vivien Henck, Nele Friedrich, Anke Hannemann, Theresa Winter, Matthias Nauck, Marcus Dörr, Martin Bahls, Stephan B Felix, Beate Stubbe, Ralf Ewert, Fabian Frost, Markus M Lerch, Hans J Grabe, Robin Bülow, Markus Otto, Norbert Hosten, Wolfgang Rathmann, Ulf Schminke, Rico Großjohann, Frank Tost, Georg Homuth, Uwe Völker, Stefan Weiss, Silva Holtfreter, Barbara M Bröker, Kathrin Zimmermann, Lars Kaderali, Marc Winnefeld, Boris Kristof, Klaus Berger, Stefanie Samietz, Christian Schwahn, Birte Holtfreter, Reiner Biffar, Stefan Kindler, Katharina Wittfeld, Wolfgang Hoffmann, Thomas Kocher

Date Published: 29th Mar 2022

Publication Type: Journal Article

Abstract

Not specified

Authors: Henry Völzke, Janka Schössow, Carsten Oliver Schmidt, Clemens Jürgens, Adrian Richter, André Werner, Nicole Werner, Dörte Radke, Alexander Teumer, Till Ittermann, Birgit Schauer, Vivien Henck, Nele Friedrich, Anke Hannemann, Theresa Winter, Matthias Nauck, Marcus Dörr, Martin Bahls, Stephan B Felix, Beate Stubbe, Ralf Ewert, Fabian Frost, Markus M Lerch, Hans J Grabe, Robin Bülow, Markus Otto, Norbert Hosten, Wolfgang Rathmann, Ulf Schminke, Rico Großjohann, Frank Tost, Georg Homuth, Uwe Völker, Stefan Weiss, Silva Holtfreter, Barbara M Bröker, Kathrin Zimmermann, Lars Kaderali, Marc Winnefeld, Boris Kristof, Klaus Berger, Stefanie Samietz, Christian Schwahn, Birte Holtfreter, Reiner Biffar, Stefan Kindler, Katharina Wittfeld, Wolfgang Hoffmann, Thomas Kocher

Date Published: 29th Mar 2022

Publication Type: Journal Article

Abstract

Not specified

Authors: Henry Völzke, Janka Schössow, Carsten Oliver Schmidt, Clemens Jürgens, Adrian Richter, André Werner, Nicole Werner, Dörte Radke, Alexander Teumer, Till Ittermann, Birgit Schauer, Vivien Henck, Nele Friedrich, Anke Hannemann, Theresa Winter, Matthias Nauck, Marcus Dörr, Martin Bahls, Stephan B Felix, Beate Stubbe, Ralf Ewert, Fabian Frost, Markus M Lerch, Hans J Grabe, Robin Bülow, Markus Otto, Norbert Hosten, Wolfgang Rathmann, Ulf Schminke, Rico Großjohann, Frank Tost, Georg Homuth, Uwe Völker, Stefan Weiss, Silva Holtfreter, Barbara M Bröker, Kathrin Zimmermann, Lars Kaderali, Marc Winnefeld, Boris Kristof, Klaus Berger, Stefanie Samietz, Christian Schwahn, Birte Holtfreter, Reiner Biffar, Stefan Kindler, Katharina Wittfeld, Wolfgang Hoffmann, Thomas Kocher

Date Published: 29th Mar 2022

Publication Type: Journal Article

Abstract

Not specified

Authors: Henry Völzke, Janka Schössow, Carsten Oliver Schmidt, Clemens Jürgens, Adrian Richter, André Werner, Nicole Werner, Dörte Radke, Alexander Teumer, Till Ittermann, Birgit Schauer, Vivien Henck, Nele Friedrich, Anke Hannemann, Theresa Winter, Matthias Nauck, Marcus Dörr, Martin Bahls, Stephan B Felix, Beate Stubbe, Ralf Ewert, Fabian Frost, Markus M Lerch, Hans J Grabe, Robin Bülow, Markus Otto, Norbert Hosten, Wolfgang Rathmann, Ulf Schminke, Rico Großjohann, Frank Tost, Georg Homuth, Uwe Völker, Stefan Weiss, Silva Holtfreter, Barbara M Bröker, Kathrin Zimmermann, Lars Kaderali, Marc Winnefeld, Boris Kristof, Klaus Berger, Stefanie Samietz, Christian Schwahn, Birte Holtfreter, Reiner Biffar, Stefan Kindler, Katharina Wittfeld, Wolfgang Hoffmann, Thomas Kocher

Date Published: 29th Mar 2022

Publication Type: Journal Article

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